A standardized protocol for repeated social defeat stress in mice
نویسندگان
چکیده
منابع مشابه
Delta Opioid Receptor Signaling Promotes Resilience to Stress Under the Repeated Social Defeat Paradigm in Mice
Axe Neurosciences, Centre de Recherche du CHU de Québec—Université Laval, Québec, QC, Canada, Centre de Recherche du CHU de Sherbrooke and Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, Département de Pharmacologie-Physiologie, Université de Sherbrooke, Sherbrooke, QC, Canada, Quebec Pain Research Network, Sherbrooke, QC, Canada, Integrated Program in...
متن کاملFelbamate reduces hormone release and locomotor hypoactivity induced by repeated stress of social defeat in mice.
Glutamatergic neurotransmission plays a role in stress hormone release and the development of mood diseases. The aim of these studies was to verify the hypothesis that repeated treatment with felbamate, an antiepileptic drug modulating glutamatergic neurotransmission, affects hormone release in response to chronic stress. A mouse model of repeated social defeat (nonaggressive male mouse repeate...
متن کاملEffects of Social Defeat Stress on Sleep in Mice
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance sta...
متن کاملProstaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice.
Various kinds of stress are thought to precipitate psychiatric disorders, such as major depression. Whereas studies in rodents have suggested a critical role of medial prefrontal cortex (mPFC) in stress susceptibility, the mechanism of how stress susceptibility is determined through mPFC remains unknown. Here we show a critical role of prostaglandin E(2) (PGE(2)), a bioactive lipid derived from...
متن کاملRepeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning
Enduring memories of sensory cues associated with drug intake drive addiction. It is well known that stressful experiences increase addiction vulnerability. However, it is not clear how repeated stress promotes learning of cue-drug associations, as repeated stress generally impairs learning and memory processes unrelated to stressful experiences. Here, we show that repeated social defeat stress...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2011
ISSN: 1754-2189,1750-2799
DOI: 10.1038/nprot.2011.361